Do SSRIs cause gastrointestinal bleeding?

doi:10.1136/dtb.2004.42317

PubMed · 15038078

Do SSRIs cause gastrointestinal bleeding?

Abstract

Selective serotonin re-uptake inhibitor antidepressants (SSRIs) can inhibit uptake, and therefore storage, of serotonin by platelets. This is significant because release of serotonin from platelets augments their aggregation; so use of SSRIs could, in theory, predispose patients to bleeding disorders. Case reports have suggested a link between SSRIs and easy bruising, nosebleeds, menorrhagia, petechial, ocular, small bowel, rectal and cerebral haemorrhages, and a prolonged bleeding time. Also, the summaries of product characteristics (SPCs) for all SSRIs include warnings about use in patients with a history of bleeding disorders or concomitant use with drugs known to affect platelet function. Here we review the risk of gastrointestinal bleeding associated with the use of SSRIs.

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Case-Control Studies Cohort Studies Gastrointestinal Hemorrhage Humans Selective Serotonin Reuptake Inhibitors Journal Article Review

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2004. Do SSRIs cause gastrointestinal bleeding?. https://doi.org/10.1136/dtb.2004.42317

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