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PubMed · 15040176

The damage-response framework of microbial pathogenesis.

Arturo Casadevall·Liise-anne Pirofski
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Abstract

The late twentieth century witnessed the emergence of numerous infectious diseases that are caused by microorganisms that rarely cause disease in normal, healthy immunocompetent hosts. The emergence of these diseases shows that the existing concepts of pathogenicity and virulence do not take into account the fact that both the microorganism and the host contribute to microbial pathogenesis. To address this impediment to studies of host-microorganism interactions, we propose a new theoretical approach to understanding microbial pathogenesis, known as the 'damage-response' framework.

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AnimalsBacteriaBacterial InfectionsBacterial Physiological PhenomenaFungiHumansInfectionsMycosesParasitesTime FactorsVirulenceVirus Physiological PhenomenaVirusesJournal ArticleReview

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Arturo Casadevall, Liise-anne Pirofski. 2003. The damage-response framework of microbial pathogenesis.. https://doi.org/10.1038/nrmicro732

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