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How good are quantitative complementation tests?

Philip M Service
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Abstract

Several recent studies have used quantitative complementation tests to identify relatively short chromosome regions that contain genes that influence life span and to screen for candidate life-span genes in flies. The methodology and logic of quantitative complementation tests are described. Arguments are presented that suggest that these tests may be misleading because there is a substantial, but unknown, likelihood of false positive results. The arguments are supported by the published results of quantitative complementation tests.

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AnimalsGenetic Complementation TestQuantitative Trait LociJournal ArticleReview

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BibTeXRIS

Philip M Service. 2004-03-24. How good are quantitative complementation tests?. https://doi.org/10.1126/sageke.2004.12.pe13

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