Human immunodeficiency virus type 1 reverse transcriptase mutation selection during in vitro exposure to tenofovir alone or combined with abacavir or lamivudine.

Chris Stone; Mounir Ait-Khaled; Charles Craig; Philip Griffin; Margaret Tisdale

doi:10.1128/aac.48.4.1413-1415.2004

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Human immunodeficiency virus type 1 reverse transcriptase mutation selection during in vitro exposure to tenofovir alone or combined with abacavir or lamivudine.

Chris Stone·Mounir Ait-Khaled·Charles Craig·Philip Griffin·Margaret Tisdale

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Abstract

Mutations selected or deselected during passage of human immunodeficiency virus strain HXB2 or resistant variants with tenofovir (TFV), abacavir (ABC), and lamivudine (3TC) differed depending on the drug combination and virus genotype. In the wild-type virus, TFV-ABC and TFV-3TC selected K65R (with reduced susceptibility to all three inhibitors) and then Y115F. TFV-containing regimens might increase K65R selection, which confers multiple nucleoside reverse transcriptase inhibitor resistance.

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Adenine Anti-HIV Agents Cloning, Molecular Dideoxynucleosides Drug Combinations Drug Resistance, Viral Genotype HIV HIV Reverse Transcriptase Humans Lamivudine Mutation Organophosphonates Organophosphorus Compounds Reverse Transcriptase Inhibitors Tenofovir Abacavir Journal Article

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Chris Stone, Mounir Ait-Khaled, Charles Craig, Philip Griffin, Margaret Tisdale. 2004. Human immunodeficiency virus type 1 reverse transcriptase mutation selection during in vitro exposure to tenofovir alone or combined with abacavir or lamivudine.. https://doi.org/10.1128/aac.48.4.1413-1415.2004

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