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DC-SIGN: binding receptor for HCV?

Zhi-Hua Feng·Quan-Chu Wang·Qing-He Nie·Zhan-Sheng Jia·Yong-Xin Zhou
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Abstract

DC-SIGN, a dendritic Cell-specific adhesion receptor and a type II transmembrane mannose-binding C-type lectin, is very important in the function of DC, both in mediating naive T cell interactions through ICAM-3 and as a rolling receptor that mediates the DC-specific ICAM-2-dependent migration processes. It can be used by viral and bacterial pathogens including Human Immunodeficiency Virus (HIV), HCV, Ebola Virus, CMV and Mycobacterium tuberculosis to facilitate infection. Both DC-SIGN and DC-SIGNR can act either in cis, by concentrating virus on target cells, or in trans, by transmission of bound virus to a target cell expressing appropriate entry receptors. Recent work showed that DC-SIGN are high-affinity binding receptors for HCV. Besides playing a role in entry into DC, HCV E2 interaction with DC-SIGN might also be detrimental for the interaction of DC with T cells during antigen presentation. The clinical strategies that target DC-SIGN may be successful in restricting HCV dissemination and pathogenesis as well as directing the migration of DCs to manipulate appropriate immune responses in autoimmunity and tumorigenic situations.

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AnimalsCell Adhesion MoleculesHepacivirusHumansLectins, C-TypeReceptors, Cell SurfaceReceptors, VirusDC-Specific ICAM-3 Grabbing NonintegrinJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Zhi-Hua Feng, Quan-Chu Wang, Qing-He Nie, Zhan-Sheng Jia, Yong-Xin Zhou. 2004-04-01. DC-SIGN: binding receptor for HCV?. https://doi.org/10.3748/wjg.v10.i7.925

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