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Toward computational systems biology.

Lingchong You
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Abstract

The development and successful application of high-throughput technologies are transforming biological research. The large quantities of data being generated by these technologies have led to the emergence of systems biology, which emphasizes large-scale, parallel characterization of biological systems and integration of fragmentary information into a coherent whole. Complementing the reductionist approach that has dominated biology for the last century, mathematical modeling is becoming a powerful tool to achieve an integrated understanding of complex biological systems and to guide experimental efforts of engineering biological systems for practical applications. Here I give an overview of current mainstream approaches in modeling biological systems, highlight specific applications of modeling in various settings, and point out future research opportunities and challenges.

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AnimalsCell Physiological PhenomenaComputational BiologyComputer SimulationGene Expression ProfilingGene Expression RegulationHumansModels, BiologicalSystems BiologyJournal ArticleResearch Support, U.S. Gov't, Non-P.H.S.Review

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Lingchong You. 2004. Toward computational systems biology.. https://doi.org/10.1385/cbb%3A40%3A2%3A167

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