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PubMed · 15055198

Lateral signaling enhances TGF-beta response complexity.

Stacey DaCosta Byfield·Anita B Roberts
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Abstract

TGF-beta elicits context-dependent and cell-specific effects that often appear conflicting, such as stimulation or inhibition of growth, apoptosis or differentiation. It is puzzling how such a diverse array of responses can result from binding of TGF-beta to a single receptor complex that activates a seemingly straightforward signal-transduction scheme dependent on shuttling of Smad transducer proteins from the receptor to the nucleus. Here, we discuss a novel paradigm for TGF-beta signaling in endothelial cells in which the same ligand can induce opposing effects mediated by activation of two different classes of Smads through a chimeric receptor complex.

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Anaplastic Lymphoma KinaseAnimalsDNA-Binding ProteinsHumansProtein-Tyrosine KinasesReceptor Protein-Tyrosine KinasesSignal TransductionSmad ProteinsTrans-ActivatorsTransforming Growth Factor betaJournal ArticleReview

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Stacey DaCosta Byfield, Anita B Roberts. 2004. Lateral signaling enhances TGF-beta response complexity.. https://doi.org/10.1016/j.tcb.2004.01.001

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