Thalidomide as a nitric oxide synthase inhibitor and its structural development.

Rumiko Shimazawa; Hiroko Sano; Aya Tanatani; Hiroyuki Miyachi; Yuichi Hashimoto

doi:10.1248/cpb.52.498

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Thalidomide as a nitric oxide synthase inhibitor and its structural development.

Rumiko Shimazawa·Hiroko Sano·Aya Tanatani·Hiroyuki Miyachi·Yuichi Hashimoto

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Abstract

Thalidomide has been found to exhibit weak nitric oxide synthase (NOS)-inhibitory activity. Structural development studies of thalidomide showed that some N-2,6-dimethylphenylhomophthalimide analogs possess NOS-inhibiting activity.

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Enzyme Inhibitors Kinetics Nitric Oxide Synthase Structure-Activity Relationship Thalidomide Journal Article Research Support, Non-U.S. Gov't

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Rumiko Shimazawa, Hiroko Sano, Aya Tanatani, Hiroyuki Miyachi, Yuichi Hashimoto. 2004. Thalidomide as a nitric oxide synthase inhibitor and its structural development.. https://doi.org/10.1248/cpb.52.498

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