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CD34-reactive trichodiscoma.

Molly Chartier·Michael L Reed·Srinivas Mandavilli·Maxwell Fung·Jane M Grant-Kels·Michael Murphy
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Abstract

BACKGROUND: Trichodiscomas are rare hamartomas of the dermal portion of the hair disc, a specialized component of the perifollicular mesenchyme. They are usually found as asymptomatic multiple skin-colored papules on the face and extremities and may have an autosomal dominant inheritance pattern. However, a solitary variant has been described. CASE REPORT: A 78-year-old woman presented with a single, non-pigmented, firm papule on the left tip of the nose, measuring 3.5 mm in diameter. RESULTS: The histological examination revealed the previously described features of a trichodiscoma. The immunohistochemical analysis showed strong immunoreactivity for CD34 in the spindle cell component. Spindle cells were negative for S-100, HMB-45, Melan-A, EMA, neurofilament, desmin, and Factor XIIIa by immunohistochemistry. CONCLUSIONS: We report strong reactivity for CD34 in the spindle cell component of a trichodiscoma. We suggest that this lesion be considered in the differential diagnosis of any CD34+ dermal spindle cell proliferation, in which an adjacent epithelial component cannot be entirely excluded.

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AgedAntigens, CD34Diagnosis, DifferentialFacial DermatosesFemaleHair DiseasesHamartomaHumansImmunohistochemistryNose DiseasesCase ReportsJournal Article

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Molly Chartier, Michael L Reed, Srinivas Mandavilli, Maxwell Fung, Jane M Grant-Kels, Michael Murphy. 2004. CD34-reactive trichodiscoma.. https://doi.org/10.1111/j.0303-6987.2004.00202.x

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