Mechanical loading influences bone mass through estrogen receptor alpha.

Karla C L Lee; Lance E Lanyon

doi:10.1097/00003677-200404000-00005

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PubMed · 15064650

Mechanical loading influences bone mass through estrogen receptor alpha.

Karla C L Lee·Lance E Lanyon

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Abstract

Mechanical loading influences bone mass and architecture through a cascade of cellular events that involve estrogen receptor alpha (ERalpha). An implication of this is that bone architecture is more adaptive to mechanical loading when the estrogen receptor number is high, as during adolescence, and less sensitive when the estrogen receptor number is low, as occurs postmenopausally, during amenorrhea, or after ovariectomy.

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Biomechanical Phenomena Bone Density Estrogen Receptor alpha Exercise Homeostasis Humans Receptors, Estrogen Stress, Mechanical Weight-Bearing Journal Article Review

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Karla C L Lee, Lance E Lanyon. 2004. Mechanical loading influences bone mass through estrogen receptor alpha.. https://doi.org/10.1097/00003677-200404000-00005

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