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PubMed · 15067197

Axin: a master scaffold for multiple signaling pathways.

Wen Luo·Sheng-Cai Lin
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Abstract

Axin was originally identified from the characterization of the Fused locus, the disruption of which leads to duplication of axis and embryonic lethality. It is a multidomain protein that interacts with multiple proteins and functions as a negative regulator of Wnt signaling by downregulating the beta-catenin levels. Recently, it was demonstrated that Axin also plays an important role in a JNK signaling pathway. Axin utilizes discriminatory domains for its distinct roles in the Wnt pathway and in the Axin/JNK pathway. Here we review the data that show how Axin regulates multiple signaling pathways by serving as a scaffold protein, controlling diverse cellular functions in proliferation, fate determination, and suppression of tumorigenesis.

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AnimalsAxin ProteinCytoskeletal ProteinsHumansMitogen-Activated Protein KinasesModels, BiologicalProto-Oncogene ProteinsRepressor ProteinsSignal TransductionTrans-ActivatorsWnt ProteinsZebrafish Proteinsbeta CateninJournal ArticleReview

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Wen Luo, Sheng-Cai Lin. Axin: a master scaffold for multiple signaling pathways.. https://doi.org/10.1159/000076563

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