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PubMed · 15068881

RNA interference against retroviruses.

Wen-Yuan Hu·Frederic D Bushman·Amara C Siva
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Abstract

Bang and Ellerman, and later Peyton Rous, reported the first identification of transmissible cancer-causing agents, which later turned out to be avian retroviruses. Today avian retroviruses are important models for study of retrovirus replication and pathogenesis, and also important pathogens of domestic fowl. Here we describe the use of RNA interference (RNAi) in live chick embryos to block replication of an avian retrovirus. We also describe inhibition of ASLV and HIV replication in cell culture with RNAi.

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AnimalsAvian Sarcoma VirusesChick EmbryoElectroporationGene Expression Regulation, ViralGenetic TherapyRNA InterferenceRNA, Small InterferingRetroviridaeTransfectionVirus ReplicationJournal ArticleReview

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Wen-Yuan Hu, Frederic D Bushman, Amara C Siva. 2004-06-01. RNA interference against retroviruses.. https://doi.org/10.1016/j.virusres.2004.01.016

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