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PubMed · 15069952

Hsp90 isoforms: functions, expression and clinical importance.

Amere Subbarao Sreedhar·Eva Kalmár·Péter Csermely·Yu-Fei Shen
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Abstract

The 90 kDa heat shock protein, Hsp90, is a main functional component of an important cytoplasmic chaperone complex, and it is involved in various cellular processes, such as cell proliferation, differentiation and apoptosis. Identification of Hsp90 as a molecular target of various anticancer drugs highlighted its importance from the clinical point of view. Here we summarize the current knowledge of various Hsp90 isoforms regarding their genomic location, molecular evolution, functional differences, differential induction after various environmental stresses and in pathological conditions as well as the growing importance of discriminating between Hsp90 isoforms in clinical practice.

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AnimalsAntineoplastic AgentsEvolution, MolecularHSP90 Heat-Shock ProteinsHumansMolecular ChaperonesNeoplasmsProtein IsoformsJournal ArticleResearch Support, Non-U.S. Gov'tReview

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BibTeXRIS

Amere Subbarao Sreedhar, Eva Kalmár, Péter Csermely, Yu-Fei Shen. 2004-03-26. Hsp90 isoforms: functions, expression and clinical importance.. https://doi.org/10.1016/s0014-5793(04)00229-7

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