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Mapping quantitative traits with random and with ascertained sibships.

Jie Peng·D Siegmund
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Abstract

Use of a robust score statistic based on a variance components model to map quantitative trait loci in randomly sampled pedigrees is reviewed. Sibships ascertained through a single proband are discussed. Under a standard assumption of multivariate normality, two suggested methods of ascertainment correction are shown to be asymptotically equivalent when the number of sibships is large.

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Chromosome MappingFemaleHumansMalePedigreeQuantitative Trait LociQuantitative Trait, HeritableRegression AnalysisSiblingsJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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Jie Peng, D Siegmund. 2004-04-14. Mapping quantitative traits with random and with ascertained sibships.. https://doi.org/10.1073/pnas.0401713101

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