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PubMed · 15089675

Nonlinear interferometric vibrational imaging.

Daniel L Marks·Stephen A Boppart
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Abstract

Coherent anti-Stokes Raman scattering (CARS) processes are "coherent," but the phase of the anti-Stokes radiation is lost by most incoherent spectroscopic CARS measurements. We propose a Raman microscopy imaging method called nonlinear interferometric vibrational imaging, which measures Raman spectra by obtaining the temporal anti-Stokes signal through nonlinear interferometry. With a more complete knowledge of the anti-Stokes signal, we show through simulations that a high-resolution Raman spectrum can be obtained of a molecule in a single pulse using broad band radiation. This could be useful for identifying the three-dimensional spatial distribution of molecular species in tissue.

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DNAImage Processing, Computer-AssistedInterferometryNucleic Acid HeteroduplexesRNASpectrum Analysis, RamanJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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Daniel L Marks, Stephen A Boppart. 2004-03-25. Nonlinear interferometric vibrational imaging.. https://doi.org/10.1103/physrevlett.92.123905

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