Adequate immunotoxicity testing in drug development.

Danuta J Herzyk; Elizabeth R Gore

doi:10.1016/j.toxlet.2003.12.026

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Adequate immunotoxicity testing in drug development.

Danuta J Herzyk·Elizabeth R Gore

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Abstract

Modulation of the immune system can lead to either immunostimulation or immunosuppression and can be either intended or unintended. While many effects on the immune system's components can be found as a result of a drug treatment or chemical exposure, true immunotoxicity occurs when such treatment results in adverse effects or defects in the immune response. Regulatory expectations to evaluate potential adverse effects of pharmaceuticals warrants a need for reliable and readily standardized methods. Moreover, criteria to classify a drug as an "immunotoxicant" need to be established. Examples of studies using a modified approach to measure T-cell-dependent antibody responses (the rat KLH model) and interpretation of the results in the context of immunotoxicity evaluation are discussed in this paper.

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Animals Antibody Formation Azathioprine Cyclosporine Drug Evaluation, Preclinical Drug-Related Side Effects and Adverse Reactions Enzyme-Linked Immunosorbent Assay Female Hemocyanins Immunity Immunoglobulin G Immunoglobulin M Immunosuppressive Agents Indicators and Reagents Male Prednisolone Rats Toxicity Tests Journal Article

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Danuta J Herzyk, Elizabeth R Gore. 2004-04-01. Adequate immunotoxicity testing in drug development.. https://doi.org/10.1016/j.toxlet.2003.12.026

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