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PubMed · 15096242

Tissue factor and tissue factor pathway inhibitor.

G C Price·S A Thompson·P C A Kam
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Abstract

The classical 'cascade/waterfall' hypothesis formulated to explain in vitro coagulation organised the amplification processes into the intrinsic and extrinsic pathways. Recent molecular biology and clinical data indicate that tissue factor/factor-VII interaction is the primary cellular initiator of coagulation in vivo. The process of blood coagulation is divided into an initiation phase followed by a propagation phase. The discovery of tissue factor pathway inhibitor further supports the revised theory of coagulation. Tissue factor is also a signalling receptor. Recent evidence has shown that blood-borne tissue factor has an important procoagulant function in sepsis, atherosclerosis and cancer, and other functions beyond haemostasis such as immune function and metastases.

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G C Price, S A Thompson, P C A Kam. 2004. Tissue factor and tissue factor pathway inhibitor.. https://doi.org/10.1111/j.1365-2044.2004.03679.x

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