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Synaptic function of cholinergic-specific Chol-1alpha ganglioside.

Susumu Ando·Yasukazu Tanaka·Satoru Kobayashi·Fumiko Fukui·Machiko Iwamoto·Hatsue Waki·Tadashi Tai·Yoshio Hirabayashi
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Abstract

The function of a cholinergic-specific ganglioside, Chol-1alpha, was investigated. The release of acetylcholine from synaptosomes was inhibited by anti-Chol-1alpha monoclonal antibody but not by monoclonal antibodies against other brain gangliosides tested. Chol-1alpha ganglioside stimulated the high-affinity choline uptake by synaptosomes and consequently enhanced acetylcholine synthesis, resulting in an increased release of acetylcholine from synaptosomes. The memory and learning abilities of rats given anti-Chol-1alpha antibody were remarkably suppressed. These in vitro and in vivo studies suggest that Chol-1alpha ganglioside plays a pivotal role in cholinergic synaptic transmission and participates in cognitive function.

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AnimalsAntibodies, MonoclonalAntigens, SurfaceChromatography, Thin LayerGangliosidesMaleRatsRats, Inbred F344Receptors, CholinergicSynapsesJournal ArticleResearch Support, Non-U.S. Gov't

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Susumu Ando, Yasukazu Tanaka, Satoru Kobayashi, Fumiko Fukui, Machiko Iwamoto, Hatsue Waki, Tadashi Tai, Yoshio Hirabayashi. 2004. Synaptic function of cholinergic-specific Chol-1alpha ganglioside.. https://doi.org/10.1023/b%3Anere.0000018860.75734.a7

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