On the electrical function of dendritic spines.

David Tsay; Rafael Yuste

doi:10.1016/j.tins.2003.11.008

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PubMed · 15102486

On the electrical function of dendritic spines.

David Tsay·Rafael Yuste

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Abstract

Dendritic spines mediate most excitatory inputs in the brain, yet their function is still unclear. Imaging experiments have demonstrated their role in biochemical compartmentalization at individual synapses, yet theoretical studies have suggested that they could serve an electrical function in transforming synaptic inputs and transmitting dendritic spikes. Recent data indicate that spines possess voltage-dependent conductances and that these channels can be spine-specific. Although direct experimental investigations of the electrical properties of spines have not yet taken place, spines could play a significant electrical role, greatly influencing dendritic integration and the function of neural circuits.

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Animals Brain Calcium Dendrites Electric Conductivity Electrophysiology Humans Membrane Potentials Models, Neurological Neurons Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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David Tsay, Rafael Yuste. 2004. On the electrical function of dendritic spines.. https://doi.org/10.1016/j.tins.2003.11.008

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