PubMed · 1510281
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M Mikulic, R Ortega. 1992. Esterase nomenclature: a confusing topic.. https://doi.org/10.1213/00000539-199209000-00042
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The structures of biological life are formed in water. Their function depends on changes in the entropy of water. It is regulated by the cholinergic system. The initiating event is the ChE-splitting of water with liberation of free protons. They will draw electrons from the fairly inert dioxygen. The induced oxygen reactivity will give liberation and transfer of electrons and hydrodynamic pH-dependent changes in protein configurations. A multitude of sub-systems will be activated. The sequence of events normally ends with the formation of water, thus preventing uncontrolled radical chain reactions. Cholinergic receptors appear as restricting units of the general disordering entropy tendency. ChE-induced hydrodynamics is propagated to the inner of cells by the water soluble protons and the electrolytes. Especially Ca appear to have a strong influence on the hydrodynamic dipole moment of water. Because water is an integral structure of DNA genetics also will be influenced. Conditions caused by deprivation of oxygen or of reactive oxygen and disorders by hyperactivity and inactivity are briefly discussed. The CNS takes the shape of a large-scale quantum computer with a function far beyond our ability of immediate perception. The atomic nuclear proportions of quantum bits (qubits) will admit the functional one-cell unit of immune memory cells. Cholinergic hydrodynamics appear to substantiate the much discussed chaos theory.
We have previously reported that Aleuria aurantia lectin (AAL)-reactive serum cholinesterase (ChE) activity increases in liver cirrhosis (LC) and hepatocellular carcinoma (HCC) compared with chronic hepatitis (CH) and normal controls (NC), and measurement of AAL-reactive ChE activity is useful in discriminating LC from CH. In the present study, we have demonstrated that the measurement of the ratio of AAL-reactive ChE to immuno-reactive ChE protein (AAL/ChE) is superior to the measurement of only AAL-reactive ChE for differentiating LC from CH. At a cut-off value of 4.0 arbitrary units of AAL/ChE, the diagnostic accuracy was 87.7%. This diagnostic accuracy is similar to that of serum hyaluronan, 88.8%. We also examined whether the AAL/ChE measurement is useful for differentiating Child's stage A LC from chronic active hepatitis (CAH) 2B. When mean + 2SD of AAL/ChE in patients with CAH2B was used as a cut-off value for the specific diagnosis of LC, the diagnostic accuracy was 70.2%. These results demonstrate that measurement of AAL/ChE is useful for discriminating LC from CH.
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