The extra cytoplasmic function sigma factor sigma(E) is essential for Mycobacterium tuberculosis virulence in mice.

Riccardo Manganelli; Lanfranco Fattorini; Dejiang Tan; Elisabetta Iona; Graziella Orefici; Giuseppe Altavilla; Paola Cusatelli; Issar Smith

doi:10.1128/iai.72.5.3038-3041.2004

PubMed · 15102817

The extra cytoplasmic function sigma factor sigma(E) is essential for Mycobacterium tuberculosis virulence in mice.

Riccardo Manganelli·Lanfranco Fattorini·Dejiang Tan·Elisabetta Iona·Graziella Orefici·Giuseppe Altavilla·Paola Cusatelli·Issar Smith

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Abstract

The virulence of a Mycobacterium tuberculosis H37Rv sigE mutant was studied in immunodeficient and immunocompetent mice. The mutant was strongly attenuated in both animal models and induced formation of granulomas with different characteristics than those induced by the wild-type strain.

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Animals Bacterial Proteins Genes, Bacterial Lung Male Mice Mice, Inbred BALB C Mice, SCID Mutation Mycobacterium tuberculosis Sigma Factor Transcription Factors Tuberculosis, Pulmonary Virulence Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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Riccardo Manganelli, Lanfranco Fattorini, Dejiang Tan, Elisabetta Iona, Graziella Orefici, Giuseppe Altavilla, Paola Cusatelli, Issar Smith. 2004. The extra cytoplasmic function sigma factor sigma(E) is essential for Mycobacterium tuberculosis virulence in mice.. https://doi.org/10.1128/iai.72.5.3038-3041.2004

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