Cell fusion and reprogramming: resolving our transdifferences.

Nemanja Rodić; Michael S Rutenberg; Naohiro Terada

doi:10.1016/j.molmed.2004.01.010

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Cell fusion and reprogramming: resolving our transdifferences.

Nemanja Rodić·Michael S Rutenberg·Naohiro Terada

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Abstract

Bone marrow-derived cells (BMDCs) can contribute to the regeneration of diverse adult tissues, including brain, liver and heart, following bone marrow transplantation. These unexpected events were initially considered a result of transdifferentiation of BMDCs, supporting the emerging idea of extended plasticity of adult stem cells. Although studies have now clearly demonstrated that spontaneous cell fusion, rather than transdifferentiation, was the primary cause for unexpected cell fate-switches of BMDCs into hepatocytes, Purkinje cells and cardiac myocytes in vivo.

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Animals Bone Marrow Cells Cell Differentiation Cell Fusion Hydrolases Mice Mice, Transgenic Regeneration Stem Cells Journal Article Review

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Nemanja Rodić, Michael S Rutenberg, Naohiro Terada. 2004. Cell fusion and reprogramming: resolving our transdifferences.. https://doi.org/10.1016/j.molmed.2004.01.010

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