Inactivating Cdc25, mitotic style.

Benjamin A Wolfe; Kathleen L Gould

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PubMed · 15107615

Inactivating Cdc25, mitotic style.

Benjamin A Wolfe·Kathleen L Gould

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Abstract

Mitotic entry and exit require activation and inactivation of the Cdk1-cyclin B kinase complex, respectively. The Cdc25 protein phosphatase family activates Cdk1-cyclin B at the G2/M transition by removing inhibitory phosphate groups. Cdc25 family members, held inactive during interphase, are activated during mitotic progression in an amplification loop involving Cdk1-cyclin B. While Cdc25 activation at the G2/M transition is required for the timely initiation of mitosis, recent evidence suggests that the inactivation of Cdc25 in late mitosis may play a role in supporting Cdk1-cyclin B inactivation. Here, we discuss the mechanisms of Cdc25 regulation and how they pertain to both mitotic entry and exit.

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Animals CDC2 Protein Kinase Cyclin B Enzyme Activation Mitosis Saccharomyces cerevisiae Proteins Xenopus laevis cdc25 Phosphatases Journal Article

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Benjamin A Wolfe, Kathleen L Gould. 2004-05-31. Inactivating Cdc25, mitotic style.. https://pubmed.ncbi.nlm.nih.gov/15107615/

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