VDJ recombination.

F W Alt; E M Oltz; F Young; J Gorman; G Taccioli; J Chen

doi:10.1016/0167-5699(92)90043-7

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PubMed · 1510813

VDJ recombination.

F W Alt·E M Oltz·F Young·J Gorman·G Taccioli·J Chen

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Abstract

The ability of lymphocyte receptor V, D and J gene segments to rearrange generates much of the receptor diversity that is the hallmark of the immune system. Naturally, the mechanisms of immunoglobulin and T-cell receptor gene recombination are of enormous interest. Here, Fred Alt and colleagues review current understanding of the process and speculate on future findings.

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Animals DNA Nucleotidyltransferases Gene Rearrangement, T-Lymphocyte Genes, Immunoglobulin Receptors, Antigen, T-Cell Recombination, Genetic Substrate Specificity VDJ Recombinases Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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F W Alt, E M Oltz, F Young, J Gorman, G Taccioli, J Chen. 1992. VDJ recombination.. https://doi.org/10.1016/0167-5699(92)90043-7

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