Nonhuman primate models for HIV vaccine development.

N L Letvin

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PubMed · 1510838

Nonhuman primate models for HIV vaccine development.

N L Letvin

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Abstract

Animal models will be essential in developing a vaccine to protect against human immunodeficiency virus (HIV) infection. While HIV-1 infects great apes, it induces no disease in these species. Some simian immunodeficiency virus (SIV) isolates cause an AIDS-like disease in macaque monkeys. The SIV/macaque model has proven a valuable system for exploring AIDS pathogenesis and assessing strategies for HIV vaccination. Studies in nonhuman primates have shown that a variety of vaccine approaches transiently elicit immunity which can protect against a very small intravenous challenge of cell-free virus. Longstanding immunity which protects against cell-associated or mucosal virus challenge has not yet been achieved. Nonhuman primate models will be essential for achieving this goal.

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AIDS Vaccines Acquired Immunodeficiency Syndrome Animals Disease Models, Animal HIV Infections Humans Immunotherapy, Active Primates Simian Acquired Immunodeficiency Syndrome Vaccination Journal Article Research Support, U.S. Gov't, P.H.S.Review

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N L Letvin. 1992. Nonhuman primate models for HIV vaccine development.. https://pubmed.ncbi.nlm.nih.gov/1510838/

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