Dendritic cells and autoimmunity.

Jagadeesh Bayry; Marina Thirion; Sandrine Delignat; Namita Misra; Sébastien Lacroix-Desmazes; Michel D Kazatchkine; Srini V Kaveri

doi:10.1016/s1568-9972(03)00104-6

PubMed · 15110229

Dendritic cells and autoimmunity.

Jagadeesh Bayry·Marina Thirion·Sandrine Delignat·Namita Misra·Sébastien Lacroix-Desmazes·Michel D Kazatchkine·Srini V Kaveri

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Abstract

Dendritic cells (DC) are professional antigen-presenting cells that are specialized in the uptake of antigens and their transport from peripheral tissues to the lymphoid organs. Because of their capacity to stimulate naive T cells, DC have a central role in the initiation of primary immune responses and are considered promising tools and targets for immunotherapy. Emerging data suggest a role for DC in initiating autoimmune attacks. Direct analysis of DC phenotypes and DC-T-cell interactions in rodent and human autoimmune diseases should shed light on how pathogenesis occurs, and suggest novel avenues of treatment aimed at alleviating deviant DC function.

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Animals Antigen Presentation Autoimmune Diseases Cell Communication Dendritic Cells Humans Mice Rats Self Tolerance T-Lymphocytes Journal Article Research Support, Non-U.S. Gov't Review

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Jagadeesh Bayry, Marina Thirion, Sandrine Delignat, Namita Misra, Sébastien Lacroix-Desmazes, Michel D Kazatchkine, Srini V Kaveri. 2004. Dendritic cells and autoimmunity.. https://doi.org/10.1016/s1568-9972(03)00104-6

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