Venusol from Gunnera perpensa: structural and activity studies.

Fatima Khan; Xolani K Peter; Rod M Mackenzie; Lynn Katsoulis; Ronette Gehring; Orde Q Munro; Fanie R van Heerden; Siegfried E Drewes

doi:10.1016/j.phytochem.2004.02.024

PubMed · 15110692

Venusol from Gunnera perpensa: structural and activity studies.

Fatima Khan·Xolani K Peter·Rod M Mackenzie·Lynn Katsoulis·Ronette Gehring·Orde Q Munro·Fanie R van Heerden·Siegfried E Drewes

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Abstract

From the aqueous extract of the dry rhizomes of Gunnera perpensa the minor components pyrogallol, succinic acid, lactic acid, and the trimethyl ether of ellagic acid glucoside were isolated. The major constituent was identified as Z-venusol, a phenylpropanoid glucoside. Its structure was verified by X-ray diffraction. Tests on isolated uterine smooth muscle from rats showed that the whole extract stimulated a direct contractile response and induced a state of continuous contractility of the uterus once all additives had been removed from the organ bath. By contrast, venusol did not trigger the direct contractile response but induced the state of continuous contractility once the organ bath was flushed.

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Animals Crystallography, X-Ray Female Glycosides Ileum Medicine, African Traditional Molecular Structure Muscle Contraction Oxytocics Phenylpropionates Plants, Medicinal Rats Rats, Sprague-Dawley Rhizome Uterine Contraction Uterus Journal Article Research Support, Non-U.S. Gov't

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Fatima Khan, Xolani K Peter, Rod M Mackenzie, Lynn Katsoulis, Ronette Gehring, Orde Q Munro, Fanie R van Heerden, Siegfried E Drewes. 2004. Venusol from Gunnera perpensa: structural and activity studies.. https://doi.org/10.1016/j.phytochem.2004.02.024

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