Targeting eNOS for stroke protection.

Matthias Endres; Ulrich Laufs; James K Liao; Michael A Moskowitz

doi:10.1016/j.tins.2004.03.009

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Targeting eNOS for stroke protection.

Matthias Endres·Ulrich Laufs·James K Liao·Michael A Moskowitz

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Abstract

Nitric oxide (NO) generated by endothelial NO synthase (eNOS) plays a crucial role in vascular function and homeostasis. NO possesses vasodilatory, anti-inflammatory, antithrombotic and antiproliferative properties. Augmentation of NO production increases cerebral blood flow, which can lead to neuroprotection during brain ischaemia. Several modalities that upregulate eNOS expression and/or activity have recently been identified, including HMG-CoA reductase inhibitors (statins), steroid hormones, nutrients and physical activity. They all increase NO bioavailability, leading to enhanced cerebral blood flow and protection from ischaemic stroke. Thus, therapeutic modalities that target eNOS not only serve as preventive measures to reduce stroke incidence but also could represent novel treatment strategies for reducing brain injury during cerebral ischaemia.

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Animals Brain Cerebrovascular Circulation Gonadal Steroid Hormones Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors Motor Activity Nitric Oxide Nitric Oxide Synthase Nitric Oxide Synthase Type III Nutritional Physiological Phenomena Stroke Up-Regulation Journal Article Research Support, Non-U.S. Gov't Review

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Matthias Endres, Ulrich Laufs, James K Liao, Michael A Moskowitz. 2004. Targeting eNOS for stroke protection.. https://doi.org/10.1016/j.tins.2004.03.009

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