PubMed · 15115934
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William Hale, Martin Floch, Robert Burakoff, Steven Itzkowitz, Bryan Warren, Scott Plevy. Indeterminate colitis.. https://doi.org/10.1097/01.mcg.0000123989.55626.38
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Retroperitoneal fibrosis (RPF) is an uncommon collagen vascular disease characterized by a chronic nonspecific inflammation of the retroperitoneum, which can entrap and obstruct retroperitoneal structures. Although obscure, an autoimmune-mediated or vasculitic etiology has been hypothesized. In the current report, a case of RPF associated with the presence of antibodies against proteinase III, which responded effectively to immunosuppressive therapy, is presented.
A study of organ-specific and organ-nonspecific autoantibodies was carried out in 21 children being followed up after a diagnosis of Kawasaki disease at a tertiary care center of North India. Anti-nuclear antibodies were detected in 9.5% patients while anti-thyroid microsomal antibodies were detected in 23.9% patients. Other autoantibodies (e.g. anti-parietal cell antibody, anti-liver kidney microsomal antibody anti-neutrophil cytoplasmic antibody, anti-mitochondrial antibody and anti-smooth muscle antibody) were not detected in any of our patients. Children with Kawasaki disease need to be monitored for the development of autoantibodies during follow-up.
Antineutrophil cytoplasm autoantibodies (ANCA) are essential for the diagnosis of small-vessel vasculitis. Information for and against their usefulness to predict relapse exists. Different approaches, using various methods and definitions, have been used to answer the role of ANCA in predicting disease relapse. Multinational, multicentric prospective studies are needed to address this question using uniform definitions and preferably the best latest tools for ANCA detection.