Urinary beta-2 microglobulin in renal dysfunction associated with hypothyroidism.

E Algün; C Topal; M Oztürk; M Ramazan Sekeroğlu; A Durmuş

doi:10.1111/j.1368-5031.2004.0014.x

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Urinary beta-2 microglobulin in renal dysfunction associated with hypothyroidism.

E Algün·C Topal·M Oztürk·M Ramazan Sekeroğlu·A Durmuş

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Abstract

Hypothyroidism is associated with a number of functional renal disorders primarily affecting water and salt handling. In this study, we aim to investigate functional renal disorders in overt and subclinical hypothyroidism. We utilised urinary beta-2 microglobulin (beta2M) as a sensitive marker of tubular dysfunction. Urinary beta2M excretion and tests for renal functions were repeated before and after T4 replacement therapy. Forty-four patients (28 with overt disease, 16 with subclinical disease) and 31 healthy control subjects were involved in the study. There was a significant increase in urinary beta2M in both overt and subclinical hypothyroidism (p < 0.05 in both). TSH levels were correlated with beta2M excretion. Effects of hypothyroidism on renal functions were readily reversible by 3 weeks of thyroid hormone replacement therapy. Urinary beta2M was a sensitive marker of renal tubular dysfunction associated with overt and subclinical hypothyroidism.

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Biomarkers Female Humans Hypothyroidism Kidney Diseases Male beta 2-Microglobulin Journal Article

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E Algün, C Topal, M Oztürk, M Ramazan Sekeroğlu, A Durmuş. 2004. Urinary beta-2 microglobulin in renal dysfunction associated with hypothyroidism.. https://doi.org/10.1111/j.1368-5031.2004.0014.x

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