Future vaccines against emerging encephalitides.

R E Johnston; N L Davis

doi:10.1007/978-3-7091-0572-6_19

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Future vaccines against emerging encephalitides.

R E Johnston·N L Davis

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Abstract

The vaccine strategies available for control of emerging encephalitides range in a continuum from traditional approaches to those utilizing new technologies. In this report, we explore the use of live attenuated vaccines where the attenuating mutations have been selected in a rational way to improve attenuation without sacrificing effectiveness. A strategy for paired lethal and resuscitating mutations is presented that will greatly reduce the possibility of reversion to virulence. Finally, we describe an example of a vaccine vector system that could be rapidly adapted for use against these virus diseases as they emerge.

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Animals Drug Design Encephalitis, Viral Humans Point Mutation Vaccination Vaccines, Attenuated Viral Vaccines Virus Replication Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Review

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R E Johnston, N L Davis. 2004. Future vaccines against emerging encephalitides.. https://doi.org/10.1007/978-3-7091-0572-6_19

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