Prolinks: a database of protein functional linkages derived from coevolution.

Peter M Bowers; Matteo Pellegrini; Mike J Thompson; Joe Fierro; Todd O Yeates; David Eisenberg

doi:10.1186/gb-2004-5-5-r35

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Prolinks: a database of protein functional linkages derived from coevolution.

Peter M Bowers·Matteo Pellegrini·Mike J Thompson·Joe Fierro·Todd O Yeates·David Eisenberg

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Abstract

The advent of whole-genome sequencing has led to methods that infer protein function and linkages. We have combined four such algorithms (phylogenetic profile, Rosetta Stone, gene neighbor and gene cluster) in a single database--Prolinks--that spans 83 organisms and includes 10 million high-confidence links. The Proteome Navigator tool allows users to browse predicted linkage networks interactively, providing accompanying annotation from public databases. The Prolinks database and the Proteome Navigator tool are available for use online at http://dip.doe-mbi.ucla.edu/pronav.

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ATP Synthetase Complexes Animals Archaeal Proteins Bacterial Proteins Benchmarking Caenorhabditis elegans Proteins Chemotaxis Contraindications Databases, Protein Drosophila Proteins Evolution, Molecular Genetic Linkage Lipopolysaccharides Phylogeny Proteins Proteomics Saccharomyces cerevisiae Proteins Comparative Study Journal Article

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Peter M Bowers, Matteo Pellegrini, Mike J Thompson, Joe Fierro, Todd O Yeates, David Eisenberg. 2004-04-16. Prolinks: a database of protein functional linkages derived from coevolution.. https://doi.org/10.1186/gb-2004-5-5-r35

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