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Stability indicating method for SPf66 antimalarial peptide in solution.

A Santoveña·M J Dorta·A Oliva·M Llabrés·M E Patarroyo·J B Fariña
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Abstract

Stability studies on the SPf66 antimalarial peptide with different pH and temperature conditions were carried out. The degradation mechanism was elucidated by the size-exclusion chromatography (SEC) technique and the experimental data obtained at 37 degrees C and different pH were fitted to a kinetic degradation model that could explain the loss of its immunogenic capacity. At 5, 25, 37, and 70 degrees C and pH 2, changes were detected in the areas of the different species, although the values obtained could not be fitted to any known degradation kinetics.

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Chromatography, GelDrug StabilityHydrogen-Ion ConcentrationMalaria VaccinesProtozoan ProteinsRecombinant ProteinsTemperatureVaccines, SyntheticJournal ArticleResearch Support, Non-U.S. Gov't

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A Santoveña, M J Dorta, A Oliva, M Llabrés, M E Patarroyo, J B Fariña. 2004. Stability indicating method for SPf66 antimalarial peptide in solution.. https://doi.org/10.1081/ddc-120030933

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