Oxidative stress, antioxidants, and endothelial function.

Eberhard Schulz; Elad Anter; John F Keaney

doi:10.2174/0929867043365369

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Oxidative stress, antioxidants, and endothelial function.

Eberhard Schulz·Elad Anter·John F Keaney

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Abstract

Endothelial dysfunction, characterized by a loss in nitric oxide bioactivity, is an early event in the development of atherosclerosis and determines future vascular complications. Emerging evidence suggests a causal role for oxidative stress in this process. Reactive oxygen species can directly inactivate nitric oxide, modulate protein function and act as cellular signaling molecules. These events contribute to the initiation and progression of endothelial dysfunction. Considerable data also indicates that antioxidant compounds limit oxidative damage and restore endothelial function. The purpose of this review is to discuss these data and suggest novel approaches for lowering the oxidative stress in the vasculature.

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Animals Antioxidants Coronary Artery Disease Endothelium, Vascular Homeostasis Humans Mitochondria NADPH Oxidases Nitric Oxide Nitric Oxide Synthase Nitric Oxide Synthase Type III Oxidative Stress Reactive Oxygen Species Xanthine Oxidase Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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Eberhard Schulz, Elad Anter, John F Keaney. 2004. Oxidative stress, antioxidants, and endothelial function.. https://doi.org/10.2174/0929867043365369

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