Notch signaling in lymphocyte development and function.

Ellen A Robey; Jeffery A Bluestone

doi:10.1016/j.coi.2004.03.009

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PubMed · 15134786

Notch signaling in lymphocyte development and function.

Ellen A Robey·Jeffery A Bluestone

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Abstract

Over the past few years, the crucial role of Notch signaling in multiple stages of T-cell development has become apparent. Recent studies have helped to define more precisely the functions and components of the Notch signaling pathway in T-cell development, including during the T versus B fate decision and in early CD4(-)CD8(-)double-negative thymocytes. In addition, new evidence points to a requirement for Notch2 in the development of marginal zone B cells. Finally, recent studies have provided our first glimpse into the complex and paradoxical roles of Notch signaling in the activation and differentiation of mature T cells.

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Animals B-Lymphocytes CD4 Antigens CD8 Antigens Cell Differentiation Humans Lymphocyte Activation Membrane Proteins Mice Receptors, Notch Signal Transduction T-Lymphocytes Thymus Gland Journal Article Research Support, U.S. Gov't, P.H.S.Review

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Ellen A Robey, Jeffery A Bluestone. 2004. Notch signaling in lymphocyte development and function.. https://doi.org/10.1016/j.coi.2004.03.009

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