Back to central tolerance.

Diane Mathis; Christophe Benoist

doi:10.1016/s1074-7613(04)00111-6

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Back to central tolerance.

Diane Mathis·Christophe Benoist

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Abstract

The establishment and maintenance of immunological tolerance entails both central and peripheral mechanisms. The latter have been highlighted in the past several years, mostly because of great interest in the activities of regulatory T cells. However, an important role for central tolerance mechanisms has been reemphasized by recent results on human autoimmune diseases, including APECED and type 1 diabetes.

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Animals Autoimmune Diseases Cell Differentiation Humans Immune Tolerance Lymphocyte Activation T-Lymphocytes Thymus Gland Transcription Factors AIRE Protein Journal Article Review

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Diane Mathis, Christophe Benoist. 2004. Back to central tolerance.. https://doi.org/10.1016/s1074-7613(04)00111-6

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