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A prospective, randomized study: day 3 versus hatching blastocyst stage.

Takafumi Utsunomiya·Hiroko Ito·Miyuki Nagaki·Junko Sato
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Abstract

BACKGROUND: Recently, advances in human IVF-embryo transfer (ET) have been reported using sequential media and blastocyst stage ET. In our previous report, using a prospective, randomized study, no advantage was found using the blastocyst stage ET compared with day 3 ET. This study was performed in order to evaluate implantation and pregnancy rates of hatching blastocyst stage ET compared with conventional day 3 ET. METHODS AND RESULTS: A total of 480 patient cycles were evaluated using a prospective, randomized study. The pregnancy rate and implantation rate were compared between the day 3 ET (n = 240) and hatching blastocyst stage ET (Hat ET; n = 240). The Hat ET group had a pregnancy rate of 29.3% (55 out of 188) and an implantation rate of 21.4% (67 out of 313). The day 3 ET group had a pregnancy rate of 29.2% (70 out of 240) and an implantation rate of 19.1% (93 out of 488). In the Hat ET group, the pregnancy rate, implantation rate and ongoing pregnancy rate of day 5 ET and day 6 ET were all higher than the respective rates in the day 7-9 ET group. CONCLUSION: We found that the pregnancy rate and implantation rate of ET with hatching stage blastocysts had no advantage compared with the conventional day 3 ET.

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AdultBlastocystEmbryo ImplantationEmbryo TransferFemaleHumansPregnancyPregnancy RateProspective StudiesClinical TrialJournal ArticleRandomized Controlled Trial

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Takafumi Utsunomiya, Hiroko Ito, Miyuki Nagaki, Junko Sato. 2004-05-13. A prospective, randomized study: day 3 versus hatching blastocyst stage.. https://doi.org/10.1093/humrep%2Fdeh288

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