Transcripts of aging.

Jan Vijg; R Brent Calder

doi:10.1016/j.tig.2004.04.007

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PubMed · 15145572

Transcripts of aging.

Jan Vijg·R Brent Calder

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Abstract

Recently, it has been demonstrated that similar alterations in gene expression profiles occur in cells from patients with Werner syndrome and from normally aged individuals. Changes involving the genes that are involved in RNA and DNA metabolism were particularly frequent - highlighting the importance of the smooth progression of replication and transcription for maintaining youthful vigor. In this article, we discuss the implications of this work for our understanding of the molecular basis of aging and the increasingly important role of microarrays for unraveling the functional pathways underlying the aging phenotype.

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Aging Cell Cycle DNA Gene Expression Gene Expression Profiling Humans Oligonucleotide Array Sequence Analysis RNA Transcription, Genetic Werner Syndrome Journal Article Review

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Jan Vijg, R Brent Calder. 2004. Transcripts of aging.. https://doi.org/10.1016/j.tig.2004.04.007

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