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Lipid rafts: microenvironments for integrin-growth factor interactions in neural development.

L Decker·W Baron·C Ffrench-Constant
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Abstract

The development of a complex multicellular organ such as the nervous system requires precise regulation of cell migration, proliferation and survival. This regulation in turn requires the integration of long-range signals, such as growth factors, with short-range cues that define the precise location and cellular neighbours for any given cell. This short review examines one integrative mechanism, integrin-growth factor receptor interactions, and explores the role of lipid rafts in the molecular mechanisms that underlie the receptor interactions.

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AnimalsCell ProliferationCell SurvivalGrowth SubstancesHumansIntegrinsMembrane MicrodomainsModels, BiologicalNeuronsOligodendrogliaPlatelet-Derived Growth FactorProtein BindingSignal TransductionJournal ArticleResearch Support, Non-U.S. Gov'tReview

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L Decker, W Baron, C Ffrench-Constant. 2004. Lipid rafts: microenvironments for integrin-growth factor interactions in neural development.. https://doi.org/10.1042/bst0320426

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