Structure and function of poly(A) binding proteins.

Uwe Kühn; Elmar Wahle

doi:10.1016/j.bbaexp.2004.03.008

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Structure and function of poly(A) binding proteins.

Uwe Kühn·Elmar Wahle

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Abstract

Poly (A) tails are found at the 3' ends of almost all eukaryotic mRNAs. They are bound by two different poly (A) binding proteins, PABPC in the cytoplasm and PABPN1 in the nucleus. PABPC functions in the initiation of translation and in the regulation of mRNA decay. In both functions, an interaction with the m7G cap at the 5' end of the message plays an important role. PABPN1 is involved in the synthesis of poly (A) tails, increasing the processivity of poly (A) polymerase and contributing to defining the length of a newly synthesized poly (A) tail.

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Animals Cell Nucleus Cytoplasm Fungal Proteins Humans Models, Biological Poly(A)-Binding Protein I Poly(A)-Binding Protein II Poly(A)-Binding Proteins Protein Binding RNA, Messenger Structure-Activity Relationship Temperature Journal Article Research Support, Non-U.S. Gov't Review

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Uwe Kühn, Elmar Wahle. 2004-05-25. Structure and function of poly(A) binding proteins.. https://doi.org/10.1016/j.bbaexp.2004.03.008

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