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Targeted ultrasound imaging using microbubbles.

Flordeliza S Villanueva·William R Wagner·Mani A Vannan·Jagat Narula
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Abstract

Targeted ultrasound imaging uses acoustically active contrast agents bearing a ligand on the surface that binds to a function-specific molecule. These ultrasound contrast agents are typically gas-filled microbubbles, nongaseous liposomes, or lipid-encapsulated perfluorocarbon emulsions. Binding of the contrast agent to the target results in persistent contrast enhancement during ultrasound imaging. This approach has been applied to the ultrasound imaging of pathophysiologic processes such as inflammation associated with ischemia reperfusion, heart transplant rejection, atherosclerotic plaque, thrombus, and apoptosis.

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AnimalsApoptosisArteriosclerosisCell AdhesionCell MovementEchocardiographyEndothelium, VascularHumansImage EnhancementLigandsMicrobubblesNeovascularization, PathologicParticle SizeSwineThrombosisUltrasonographyJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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Flordeliza S Villanueva, William R Wagner, Mani A Vannan, Jagat Narula. 2004. Targeted ultrasound imaging using microbubbles.. https://doi.org/10.1016/j.ccl.2004.02.008

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