Leptin signaling.

Rexford S Ahima; Suzette Y Osei

doi:10.1016/j.physbeh.2004.02.014

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Leptin signaling.

Rexford S Ahima·Suzette Y Osei

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Abstract

The discovery of leptin was a major breakthrough in our understanding of the role of adipose tissue as a storage and secretory organ. Leptin was initially thought to act mainly to prevent obesity; however, studies have demonstrated profound effects of leptin in the response to fasting, regulation of neuroendocrine and immune systems, hematopoiesis, bone and brain development. This review will focus on the signaling pathways which mediate these diverse effects of leptin in the brain and other physiologic systems.

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Animals Brain Energy Metabolism Homeostasis Hormones Humans Leptin Mutation Neural Pathways Receptors, Cell Surface Receptors, Leptin Signal Transduction Journal Article Research Support, U.S. Gov't, P.H.S.Review

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Rexford S Ahima, Suzette Y Osei. 2004. Leptin signaling.. https://doi.org/10.1016/j.physbeh.2004.02.014

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