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PubMed · 15166790

Electronegative low-density lipoprotein.

José Luis Sánchez-Quesada·Sonia Benítez·Jordi Ordóñez-Llanos
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Abstract

PURPOSE OF REVIEW: The occurrence in blood of an electronegatively charged LDL was described in 1988. During the 1990s reports studying electronegative LDL (LDL(-)) were scant and its atherogenic role controversial. Nevertheless, recent reports have provided new evidence on a putative atherogenic role of LDL(-). This review focuses on and discusses these new findings. RECENT FINDINGS: In recent years, LDL(-) has been found to be involved in several atherogenic features through its action on cultured endothelial cells. LDL(-) induces the production of chemokines, such as IL-8 and monocyte chemotactic protein 1, and increases tumor necrosis factor-alpha-induced production of vascular cell adhesion molecule 1, with these molecules being involved in early phases of leukocyte recruitment. LDL(-) from familial hypercholesterolemic patients also decreases DNA synthesis and intracellular fibroblast growth factor 2 production, which may contribute to impaired angiogenesis and increased apoptosis. In addition, the preferential association of platelet-activating factor acetylhydrolase with LDL(-) has been reported, suggesting a proinflammatory role of this enzyme in LDL(-). SUMMARY: Recent findings suggest that LDL(-) could contribute to atherogenesis via several mechanisms, including proinflammatory, proapoptotic and anti-angiogenesis properties. Further studies are required to define the role of LDL(-) in atherogenesis more precisely and to clarify mechanisms involved in endothelial cell activation.

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AnimalsArteriosclerosisCardiovascular DiseasesElectricityEndothelium, VascularFibroblast Growth Factor 2HumansInflammationInterleukin-8Lipoproteins, LDLRiskTumor Necrosis Factor-alphaVascular Cell Adhesion Molecule-1Journal ArticleResearch Support, Non-U.S. Gov'tReview

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José Luis Sánchez-Quesada, Sonia Benítez, Jordi Ordóñez-Llanos. 2004. Electronegative low-density lipoprotein.. https://doi.org/10.1097/00041433-200406000-00014

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