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PubMed · 15169384

Pulling tethers from adhered vesicles.

Ana-Suncana Smith·Erich Sackmann·Udo Seifert
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Abstract

The competition between adhesion and tether formation in bound vesicles is investigated. A theoretical model is developed in which tethers are induced by the application of a pulling force to the top of a strongly adhered vesicle. A critical onset force is identified where the tether spontaneously appears as part of a first order shape transition. Further growth of the tether initiates a detachment process that culminates in a continuous unbinding of the vesicle at a finite detachment force. Both critical forces, as well as all shape parameters, are calculated as a function of the reduced volume and the strength of adhesive potential.

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Cell AdhesionCytoplasmic VesiclesMembranesModels, BiologicalModels, TheoreticalThermodynamicsJournal ArticleResearch Support, Non-U.S. Gov't

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Ana-Suncana Smith, Erich Sackmann, Udo Seifert. 2004-05-21. Pulling tethers from adhered vesicles.. https://doi.org/10.1103/physrevlett.92.208101

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