PubMed Health⌕ Search
Home/Archive/PubMed

PubMed · 1517003

Basophil degranulation control.

B Hadjaj·Y Cherruault·J Sainte Laudy
View original source ↗Export metadata ↓

Abstract

We first present a global simulation model describing inhibition of human basophil degranulation by means of high dilutions. Then we study an optimal control problem associated to a non-linear compartmental model. This control is associated to an antigen concentration. For solving this control problem we used a dynamic programming method.

Explore related subjects

Basophil Degranulation TestComputer SimulationHumansQuality ControlComparative StudyJournal Article

Keep this discovery

Explore connections, maps & timelines

BibTeXRIS

B Hadjaj, Y Cherruault, J Sainte Laudy. 1992. Basophil degranulation control.. https://doi.org/10.1016/0020-7101(92)90065-z

Cite the original work for its findings. Save a collection to share your selection of sources.

KEEP EXPLORING

Related citations

PubMed1990

High-performance liquid chromatographic method for the evaluation of possible interferences in basophil-histamine release measurements.

Basophil activation studies commonly rely on the measurement of histamine following extraction and condensation to o-phthalaldehyde (OPT) as a quantitative measurement of degranulation. Specificity has long been recognized as a problem with this method. We have described a new high-performance liquid chromatographic method that allows for both a qualitative and a quantitative check of the purity of the OPT-histamine adduct. This method was sensitive (limit of detection = 2.55 pmol) and linear over a wide range (5 to 1000 ng/ml).

Basophil Degranulation Test↗
PubMed1990

Reactivity of human basophils to anti-IgE and protein A in atopic dermatitis.

We compared by basophil degranulation and histamine release the reactivity to protein A and anti-IgE of the basophils from 3 groups of patients: group I (blood donors), group II (rhinitis) and group III (atopic dermatitis). We demonstrated that histamine release and basophil degranulation gave tightly correlated results and that by both methods group III was significantly (p less than 0.01) more sensitive to the effectors than the two other groups. Protein A and anti-IgE stimulation curves showed a rebound effect at low concentrations of effectors. This was, however, only significant (p less than 0.01) for group III. Bacterial hypersensitivity may be IgE-mediated and may be related to the increased sensitivity to bacterial antigens and the severity of atopic dermatitis in patients infected by Staphylococcus aureus.

Basophil Degranulation Test↗