Retinoid glucuronides do not interact with retinoid binding proteins.

R G Mehta; A B Barua; J A Olson; R C Moon

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PubMed · 1517036

Retinoid glucuronides do not interact with retinoid binding proteins.

R G Mehta·A B Barua·J A Olson·R C Moon

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Abstract

Retinoid glucuronides have recently been described as water soluble, biologically active retinoids. In mouse mammary gland organ cultures retinoyl glucuronide, a retinoic acid counterpart, inhibited hormone induced differentiation. In this report we examined whether the effects of retinoyl and retinyl glucuronides are mediated by specific retinoid binding protein in mammary glands in organ culture. Results indicated that neither retinoyl nor retinyl glucuronide competed for cytosolic retinoic acid or retinol binding proteins respectively. These results indicate that either the effects of retinoid glucuronides are independent of retinoid binding proteins or they have to be metabolized to an active component which may in turn bind to retinoid binding protein for the glucuronide action.

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Animals Female Glucuronates Mammary Glands, Animal Mice Mice, Inbred BALB C Organ Culture Techniques Retinoids Retinol-Binding Proteins Journal Article Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.

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R G Mehta, A B Barua, J A Olson, R C Moon. 1992. Retinoid glucuronides do not interact with retinoid binding proteins.. https://pubmed.ncbi.nlm.nih.gov/1517036/

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