Reflections on CD8 T-cell activation and memory.

David Masopust; Rafi Ahmed

doi:10.1385/ir:29:1-3:151

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Reflections on CD8 T-cell activation and memory.

David Masopust·Rafi Ahmed

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Abstract

CD8 T cells contribute to clearance and long-term protection following acute infection with certain viruses, bacteria, and protozoa, and may play an important role in tumor immunity. Primary adaptive CD8 T-cell responses have been conceptually divided into four phases: activation, expansion, contraction, and memory. We summarize each phase of the response, and discuss recent advances in our understanding of the development and maintenance of CD8 T-cell memory.

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Animals CD8-Positive T-Lymphocytes Humans Immunologic Memory Lymphocyte Activation Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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David Masopust, Rafi Ahmed. 2004. Reflections on CD8 T-cell activation and memory.. https://doi.org/10.1385/ir%3A29%3A1-3%3A151

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