Process optimization using combinatorial design principles: parallel synthesis and design of experiment methods.

Owen W Gooding

doi:10.1016/j.cbpa.2004.04.009

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Process optimization using combinatorial design principles: parallel synthesis and design of experiment methods.

Owen W Gooding

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Abstract

The use of parallel synthesis techniques with statistical design of experiment (DoE) methods is a powerful combination for the optimization of chemical processes. Advances in parallel synthesis equipment and easy to use software for statistical DoE have fueled a growing acceptance of these techniques in the pharmaceutical industry. As drug candidate structures become more complex at the same time that development timelines are compressed, these enabling technologies promise to become more important in the future.

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Combinatorial Chemistry Techniques Pharmaceutical Preparations Research Design Software Statistics as Topic Technology, Pharmaceutical Journal Article Review

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Owen W Gooding. 2004. Process optimization using combinatorial design principles: parallel synthesis and design of experiment methods.. https://doi.org/10.1016/j.cbpa.2004.04.009

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