Platelet function in term and preterm neonates.

Matthew A Saxonhouse; Martha C Sola

doi:10.1016/j.clp.2004.03.009

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PubMed · 15183653

Platelet function in term and preterm neonates.

Matthew A Saxonhouse·Martha C Sola

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Abstract

Platelet dysfunction likely contributes to the pathophysiology of catastrophic hemorrhages in preterm neonates. In vitro studies have demonstrated that platelets of both term and preterm neonates are hyporesponsive to a variety of agonists. In contrast,template bleeding times of term neonates are shorter than those from adults. Very little is known about this and other tests of primary hemostasis in premature and sick neonates in the neonatal intensive care unit (NICU). This article covers the current knowledge of platelet function in preterm and term neonates and review show new agents (such as recombinant thrombopoietin and recombinant factor VIIa) may enhance neonatal platelet function.

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Blood Platelets Cerebral Hemorrhage Factor VIIa Humans Infant, Newborn Infant, Premature Platelet Function Tests Recombinant Proteins Thrombopoietin Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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Matthew A Saxonhouse, Martha C Sola. 2004. Platelet function in term and preterm neonates.. https://doi.org/10.1016/j.clp.2004.03.009

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