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PubMed · 15190478

[TBP, a universal transcription factor?].

Irwin Davidson·Igor Martianov·Stéphane Viville
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Abstract

The TATA binding protein (TBP) is a subunit of several macromolecular complexes required for transcription by the three nuclear RNA polymerases. This observation led to the idea that TBP is a "universal" transcription factor. The discovery of three TBP-related factors and a macromolecular complex which lacks TBP but can support RNA polymerase II transcription in vitro has led to a reappraisal of the universal character of TBP. Several in vivo studies have rather shown that TBP plays a specific role in the activation of a subset of cellular genes controlling the cell cycle. In mammals, the aminoterminal region of TBP plays a highly selective role in the maternal immunotolerance of pregnancy.

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AnimalsCell CycleFemaleMammalsPregnancyTATA-Box Binding ProteinTranscription, GeneticEnglish AbstractJournal ArticleResearch Support, Non-U.S. Gov'tReview

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Irwin Davidson, Igor Martianov, Stéphane Viville. 2004. [TBP, a universal transcription factor?].. https://doi.org/10.1051/medsci%2F2004205575

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